TACC Research Forum
AutismS: from Interactive Social Neuroscience to Personalized Multiscale Psychiatry
Our next TACC Research Forum will feature Dr. Guillaume Dumas, Assistant Professor in Computational Psychiatry at the Faculty of Medicine at the Université de Montréal.
Abstract: To understand human cognition in its functioning and dysfunctions, it is necessary to combine multiple scales of observation and related disciplines from the molecular level in genetics to the behavioural level in psychology. In psychiatry, diagnosis, prognostic evaluation and choice of treatment thus require the integration of multiple pieces of information and their temporal evolution, particularly for neurodevelopmental disorders. This talk illustrates how the construction of “stairs” between scales provides heuristic alternatives to understand how we get to understand others: a crucial aspect of autism. I will argue that recent advances in integrative neuroscience and computational biology finally provide all the conceptual and methodological tools to develop the necessary social physiology for precision psychiatry. About integrative neuroscience, I will describe how recent efforts in human-human and human-machine interaction have brought more ecological paradigms to the laboratory for the study of human social cognition and its physiological anchoring. Concerning computational biology, I will present how large longitudinal cohorts can achieve the deep genotyping and phenotyping necessary for modern artificial intelligence tools to move beyond the traditional patient-to-control dichotomy to stratification methods or more dimensional models (e.g. RDoC). In conclusion, I will discuss ways to integrate these two approaches for addressing the challenge of precision psychiatry.
Summary: Dr. Guillaume Dumas is Assistant Professor in Computational Psychiatry of the Faculty of Medicine at the University of Montréal and the Director of the Precision Psychiatry and Social Physiology laboratory in the CHU Sainte-Justine research center. He holds the IVADO Chair in “AI and Mental Health”, the FRQS J1 grant in “AI and Digital Health”, and is an affiliated academic member of Mila – Quebec Artificial Intelligence Institute. He is also an affiliate member of the Human Brain and Behavior Laboratory, in the Center for Complex Systems and Brains Sciences of Florida Atlantic University. Dr. Dumas investigates the neurobiology of social cognition through the lens of complex systems theory and computational methods. His scientific interests connect with biomedical research, specifically in psychiatry, which requires to integrate biological, psychological, and social dimensions of the human mind. His interdisciplinary team develops new approaches to psychiatry, from digital tools for assessment and rehabilitation to mathematical modelling for clinical decision-making and precision medicine. Dr. Dumas also participates in numerous projects at the interface between Science, Art, and Society, from raising awareness about open science to maintaining citizens’ rights in terms of cognitive freedom.